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The botulinic toxin is a substance which decreases the muscle contraction by acting at the level of the neuro-muscular jonction (myorelaxing action).
The botulinic toxin, under the name of “BOTOX” received, in USA, the Food and Drug Administration (FDA) authorization in 2002 for its use to treat the wrinckles in between the two eyebrows.
In practice, the more usual indications for botulinic toxin aesthetical injections are the wrinckles between the two eyebrows, the frontal lines and the crow-feet wrinckles.
The principle of botulinic toxin consists of using its muscular release properties.
The main goal, we want to reach, is to obtain a decreased muscular action at the level of the forhead and the eyebrows , in order to decrease either the horizontal wrinckles and the vertical ones, done by muscles contraction.
Such a use allows to smooth the skin reliefs and so to get a rejuvenative effect due to the muscular tension release.
From a more global point of view, we must know that the brow position is fixed by the balance of two opposite forces, one corresponding to lowering muscles (located around the eyebrow) and the other one corresponding to one elevating muscle (the frontalis muscle).
The horizontal wrinckles are due to the contraction of the frontalis muscle, and the vertical ones are due to the contraction of the lowering muscles.
This treatment main goal is to improve wrinckles and fine lines, when in a resting position and not to avoid muscle contraction. So, the result will be judge especially on the wrinckles aspect of a quiet face.
Concerning the balance between the lowering and elevating muscles, the botulinic toxin, by reducing the action of one muscles group, decrease the wrinckles related to these muscles and free, at the same time, the action the opposed muscles : our aim is to treat the muscular balance, in order to
obtain so a facial harmony.
The botulinic toxin treatment must be done and think with time : so, it is recommand, at the time of the first sesion, to treat progressively and to avoid the risk of ”doing too much”.
We should prefer a moderately efficient first session then a too efficient one : so, we don’t think, it is suitable to target an optimum as soon as the first injection. In certain cases, it can be necessary to practice several sessions before adapting, for the best, this treatment potentialities, in respect with patient particularities.


No need for special preparation. We must also respect the following contra-indications :

  • Certain neuromuscular deseases, like myasthenia
  • Pregnancy and breast feeding
  • Known hypersensibility to botulinic neurotoxin A or to serum-albumin
  • Present treatment with antibiotics from the aminosid group (Amiklin, Gentallin)



No anaesthesia is needed


This treatment consists on a serie of facial injections. The needle is fine and the injections are usually less painful.
The time treatment is a few minutes.


During the two hours following the injections, it is advised not doing itense sport and not lying down. It is also advised to avoid facial manipulation or massage for 24 hours following the session.
It is very important to minimize the risks of bruises or bleeding at the treated area, for 15 days before and after injections, in order to avoid the injected substance to run away to muscles around what could produce undesirable side effects.
Usually, the after injection is light. Some slightly swollen marks may stay for 20 to 30 minutes before disappearing. The patients can go back to their normal life after the injections.

Some rares undesirables but transitory effects may occur like:

  • Redness at the injected points, rarely persisting more than 3 to 6 days
  • Ecchymosis (bruises), rarely observed and may stay a couple of days
  • Edema : a swelling, more often around the eyes, may appear progressively within 4 to 5 days and then decrease within a few days or weeks.
  • Sensibility failure : an impression of tension or fixity of the forhead, mouth or neck , depending on the treated area, as well as a modified sensibility, related to the feeling of a “cardboard” skin, may stay for a few days.
  • Ocular or facial fugacious pains : such pains have been described in the treated region but remain exceptional

Whatever, if you have any worry in the post injection period, don’t hesitate to contact your physician. Bruising have settled the final result will begin to be visible 2 to 3 weeks after the procedure.


The expected result consists of wrinckles decreasing with small motions keeping; it is obtained within 3 to 15 days following the injections.
Effects : you can see the result after a few days, but for about 15 days, the effects on the face may be variable (even sometimes possibly asymetrical) before ending to stabilize.
The result obtained after the first session stays 3 to 6 months averagely, after what the injection can be renewed.
Injection frequency : the injections have to be done several times, with space of 3 to 6 months, before getting a quite stable result.
Starting after the second injection, the results may stay longer ( 6 to 8 months). It is then suitable to repeat the injections every 3 to 6 months.
But we recommand never reinjecting after a period of time of less than 3 months, to avoid, especially, to cteate a resistance to the substance, due to like “a vaccination effect”.
The result on the face aspect can be stabilized after 3 sessions but, in certains cases, we may need at least 8 to 10 sessions to get a quite stable result.
On the other way, we must remark that if we stop injecting, the treated muscle will go back to its normal function, from before the injections.


Localized imperfections
In a few cases, some localized imperfections (persistance of small wrinckles) may be seen without speaking of real complication. They depend to the previous aspect of the skin, already marked with deep indelible “fracture” due to the oldness of the wrinckle.
It may also exists insufficient or even asymetrical results : they are related to the fact, we have more or less strong muscles and often asymetrical too.
These imperfections are usually treated with a complementary botulinic toxin injection, a month after th injection.
Concerning this, we must underline that if a localized complementary injection may be indicated to improve the result, it shouldn’t be done before 15 days after the session because the balance between the different muscles takes 15 days to set up.


The complications are very rares. The possible complications are the followings :

Facial complications

  • Headache : it can appear after the first injections and disappear within a few hours to a few days
  • Eyebrow ptosis : frontal injection may produce a slight droping of the eyebrows. This is generally due to a previous low position of the eyebrows. It will usually regress within a few weeks.
  • Eyelid ptosis : the injection of the glabella region may induce a partial droping of the upper eyelid which can stay for 4 to 8 weeks. This is quite rare (less than 1% of the cases) and always disappear within a few weeks.
  • Smiling and swallowing discomfort : lips injection may induce a smiling discomfort or small abnormal movements. The neck injection may produce swallowing difficulties.
  • Eye dryness : due to a decrease tear’s secretion, which can produce a keratis, especially on patient wearing contact lens (be aware to well hydrate the cornea)
  • Paradoxical muscle contraction and mimic disturbance : in the days following injection, the
    muscles may present some paradoxical movements (spontaneous contraction) whithout any gravity.

General complications They are absoluteley exceptional.

  • Allergic reaction: cutaneous rash, urticaria, general allergic reaction
  • Nausea, vertigo
  • Tiredness, fever, flu syndrom
  • Skin and buccal dryness







Dr. Roland Tohme MD